GPR54-Dependent Stimulation of Luteinizing Hormone Secretion by Neurokinin B in Prepubertal Rats

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

GPR54-Dependent Stimulation of Luteinizing Hormone Secretion by Neurokinin B in Prepubertal Rats

Kisspeptin, neurokinin B (NKB) and dynorphin A (Dyn) are coexpressed within KNDy neurons that project from the hypothalamic arcuate nucleus (ARC) to GnRH neurons and numerous other hypothalamic targets. Each of the KNDy neuropeptides has been implicated in regulating pulsatile GnRH/LH secretion. In isolation, kisspeptin is generally known to stimulate, and Dyn to inhibit LH secretion. However, ...

متن کامل

Hypothalamic KiSS1/GPR54 Gene Expressions and Luteinizing Hormone Plasma Secretion in Morphine Treated Male Rats

Objective The inhibitory effects of Morphine and the stimulatory influence of kisspeptin signaling have been demonstrated on GnRH/LH release. Hypothalamic kisspeptin is involved in relaying the environmental and metabolic information to reproductive axis. In the present study the role of kisspeptin/GPR54 signaling system was investigated on relaying the inhibitory effects of morphine on LH horm...

متن کامل

Luteinizing hormone secretion as influenced by age and estradiol in the prepubertal gilt.

The aim of this study was to determine if there is an age related reduction in the sensitivity of the negative feedback action of 17β-estradiol (estradiol) on luteinizing hormone (LH) secretion in the prepubertal gilt. Ovariectomized gilts at 90 (n=12), 150 (n=11) or 210 (n=12) days of age received estradiol benzoate (EB) osmotic pump implants 6/group and the remaining animals received vehicle ...

متن کامل

A circadian rhythm of luteinizing hormone secretion in ovariectomized rats.

Physiol, 214(2): 213-217. 1968.-The possibility of a circadian pattern of luteinizing hormone (LH) synthesis and release was investigated by measuring LH in pituitary and plasma samples collected at 4-hr intervals over a 24-hr period from ovariectomized rats. Some of the rats had been pretreated with PMSG or HCG before prepuberal ovariectomy; other rats which were not injected were ovariectomiz...

متن کامل

Regulation of luteinizing hormone secretion in prepubertal heifers: increased threshold to negative feedback action of estradiol.

Three experiments were conducted to evaluate negative feedback action of estradiol-17 beta (E2) on luteinizing hormone (LH) release in ovariectomized heifers and to determine the response at different ages. In the first experiment, iv injections of .2 or 2.0 micrograms E2/kg body weight (BW) reduced serum concentrations of LH by arresting episodic mode of secretion. Results of a second experime...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: PLoS ONE

سال: 2012

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0044344